Medical image biomarkers of cancer promise improvements in patient care through advances in precision medicine. Compared to genomic biomarkers, image biomarkers provide the advantages of being a non-invasive procedure, and characterizing a heterogeneous tumor in its entirety, as opposed to limited tissue available for biopsy. We developed a unique radiogenomic dataset from a Non-Small Cell Lung Cancer (NSCLC)...
This data collection consists of images acquired in preparation for NRG-1308, a phase 3 randomized trial to compare overall survival after photon versus proton chemoradiation therapy for inoperable stage II-IIIB NSCLC. The images include IMRT photon and proton scans. A detailed summary of the full trial from which these patients were included...
In order to assess mechanisms predictive of response or resistance to intense neoadjuvant therapy, we performed automated immunohistochemistry on targeted biopsies from patients with intermediate or high risk prostate cancer. All biopsy were stained with H&E or antibodies against: p53, PTEN, AR, PSA, GR, Ki67, SYP and PIN4-cocktail (p63+CK5+K18+AMACR). We further performed automated immunohistochemistry on whole...
This is a collection of F-18 NaF positron emission tomography/computed tomography (PET/CT) images in patients with prostate cancer, with suspected or known bone involvement.
Imaging was performed on a Phillips Gemini TF PET/CT scanner based on 4x4x22mm LYSO (lutetium yttrium orthosilicate) crystal detection elements covering 18cm axial field of view (FOV) and 57cm imaging transaxial FOV. The time of flight resolution...
This collection comprises multi-parametric magnetic resonance imaging (mpMRI) scans for de novo Glioblastoma (GBM) patients from the University of Pennsylvania Health System, coupled with patient demographics, clinical outcome (e.g., overall survival, genomic information, tumor progression), as well as computer-aided and manually-corrected segmentation labels of multiple histologically distinct tumor sub-regions, computer-aided...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with incidences doubled over the past two decades due to increasing risk factors. Despite surveillance, the majority of HCC cases are diagnosed at advanced stages that can be treated only using (Transarterial chemoembolization) TACE, or systemic therapy. TACE failure can occur to 60% of patients receiving the procedure, with subsequent financial...
This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of breast cancer. These images were acquired as part of a Department of Defense (DOD) Breast Cancer Research Program (BCRP) Postdoctoral Award W81XWH-12-1-0307 entitled “Investigating Ductal Carcinoma in Situ Using Noninvasive Imaging of Genetically Engineered Mouse Models
A particular emphasis of...
This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of high grade astrocytoma, including glioblastoma multiforme (GBM).
In these GEMMs, the most commonly disregulated networks in GBM -- RB, KRAS and/or PI3K signaling -- are perturbed at the genetic level. These genetic aberrations induce development of high grade astrocytoma in the mouse with properties...
Microscopic images were captured from bone marrow aspirate slides of patients diagnosed with multiple myeloma as per the standard guidelines. Slides were stained using Jenner- Giemsa stain. Images were captured at 1000x magnification using Nikon Eclipse-200 microscope equipped with a digital camera. Images were captured in raw BMP format with a size of 2560x1920 pixels. In all, this dataset consists of 85 images. All...
