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HEAD-NECK-RADIOMICS-HN1

HEAD-NECK-RADIOMICS-HN1 | HEAD-NECK-RADIOMICS-HN1

DOI: 10.7937/tcia.2019.8kap372n | Data Citation Required | Image Collection

Location Species Subjects Data Types Cancer Types Size Supporting Data Status Updated
Head-Neck Human 137 CT, PT, RTSTRUCT, SEG Head and Neck Cancer 11.79GB Clinical Limited, Complete 2020/07/29

Summary

This collection contains clinical data and computed tomography (CT) from 137 head and neck squamous cell carcinoma (HNSCC) patients treated by radiotherapy. For these patients a pre-treatment CT scan was manual delineated by an experienced radiation oncologist of the 3D volume of the gross tumor volume. This dataset refers to the "H&N1" dataset of the study published in Nature Communications (http://doi.org/10.1038/ncomms5006). At time of previous publication, images of one subject had been unintentionally overlooked. In short, the publication used a radiomics approach to computed tomography data of 1,019 patients with lung or head-and-neck cancer.

Radiomics refers to the comprehensive quantification of tumor phenotypes by applying a large number of quantitative image features. In the published analysis, 440 features quantifying tumor image intensity, shape, and texture were extracted. We found that a large number of radiomic features have prognostic power in independent data sets, many of which were not identified as significant before. Radiogenomics analysis revealed that a prognostic radiomic signature, capturing intra-tumor heterogeneity, was associated with underlying gene-expression patterns. These data suggest that radiomics identifies a general prognostic phenotype existing in both lung and head-and-neck cancer. This may have a clinical impact as imaging is routinely used in clinical practice, providing an unprecedented opportunity to improve decision-support in cancer treatment at low cost.

This dataset is provided as open access to support repeatability and reproducibility of research in radiomics. This dataset will be the subject of an upcoming article addressing FAIR radiomics practices to support transparency, harmonization and collaboration on radiomics.

From version 2 (release date 09/20/2019) onwards we included the primary neoplasm gross tumour volume delineations in DICOM SEGMENTATION as well as DICOM RTSTRUCT files that accompanied the DICOM axial images. This dataset is provided as open access to support repeatability and reproducibility of research in radiomics. This dataset will be the subject of an upcoming article addressing FAIR radiomics practices to support transparency, harmonization and collaboration on radiomics.

Other data sets in the Cancer Imaging Archive that were used in the same study published in Nature Communications: NSCLC-Radiomics,  NSCLC-Radiomics-Genomics, NSCLC-Radiomics-Interobserver1, RIDER-LungCT-Seg.

Data Access

Some data in this collection contains images that could potentially be used to reconstruct a human face. To safeguard the privacy of participants, users must sign and submit a TCIA No Commercial Limited Access License to help@cancerimagingarchive.net before accessing the data.

Version 3: Updated 2020/07/29

Added the chemotherapy schedule to the clinical data; one extra column added which is “chemotherapy_given”.

Added data dictionary for clinical data.

Title Data Type Format Access Points Subjects Studies Series Images License
Images, Segmentations, and Radiation Therapy Structures SEG, RTSTRUCT, CT, PT DICOM
Download requires NBIA Data Retriever
 137 137 486 28,918 TCIA No Commercial Limited
Clinical Data Demographic, Follow-Up ZIP and CSV 137 CC BY-NC 3.0
Data Dictionary TXT CC BY-NC 3.0

Citations & Data Usage Policy

Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:

Data Citation

Wee, L., & Dekker, A. (2019). Data from HEAD-NECK-RADIOMICS-HN1 [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/tcia.2019.8kap372n

Acknowledgements

We would like to acknowledge the individuals and institutions that have provided data for this collection:

  • Leonard Wee, MAASTRO (Dept of Radiotherapy), Maastricht University Medical Centre+, Maastricht, Limburg, The Netherlands.
  • Frank Hoebers, MAASTRO (Dept of Radiotherapy), Maastricht University Medical Centre+, Maastricht, Limburg, The Netherlands.
  • Andre Dekker, MAASTRO (Dept of Radiotherapy), Maastricht University Medical Centre+, Maastricht, Limburg, The Netherlands.
  • Hugo Aerts, Computational Imaging and Bioinformatic Laboratory, Dana-Farber Cancer Institute & Harvard Medical School, Boston, Massachusetts, USA.

Other Publications Using this Data

TCIA maintains a list of publications which leverage our data. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.

  1. Bielak, L., Wiedenmann, N., Berlin, A., Nicolay, N. H., Gunashekar, D. D., Hagele, L., . . . Bock, M. (2020). Convolutional neural networks for head and neck tumor segmentation on 7-channel multiparametric MRI: a leave-one-out analysis. Radiat Oncol, 15(1), 181. doi:https://doi.org/10.1186/s13014-020-01618-z
  2. Choi, Y., Nam, Y., Jang, J., Shin, N. Y., Ahn, K. J., Kim, B. S., . . . Kim, M. S. (2020). Prediction of Human Papillomavirus Status and Overall Survival in Patients with Untreated Oropharyngeal Squamous Cell Carcinoma: Development and Validation of CT-Based Radiomics. AJNR Am J Neuroradiol, 41(10), 1897-1904. doi: https://doi.org/10.3174/ajnr.A6756
  3. Gifford, R. C. (2022). Deep Learning Architecture to Improve Edge Accuracy of Auto-Contouring for Head and Neck Radiotherapy. (Master of Science MS). Ohio State UNiversity, Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1658317931555616
  4. Giraud, P., Giraud, P., Nicolas, E., Boisselier, P., Alfonsi, M., Rives, M., . . . Chajon, E. (2021). Interpretable Machine Learning Model for Locoregional Relapse Prediction in Oropharyngeal Cancers. Cancers, 13(1), 57. doi:https://doi.org/10.3390/cancers13010057
  5. Kalendralis, P. (2022). Artificial intelligence applications in radiotherapy: The role of the FAIR data principles. (Ph.D. Dissertation). Maastricht University ,The Netherlands, Available from https://doi.org/10.26481/dis.20221010pk
  6. Kalendralis, P., Shi, Z., Traverso, A., Choudhury, A., Sloep, M., Zhovannik, I., . . . Wee, L. (2020). FAIR-compliant clinical, radiomics and DICOM metadata of RIDER, interobserver, Lung1 and head-Neck1 TCIA collections. Med Phys. doi:https://doi.org/10.1002/mp.14322
  7. La Greca Saint-Esteven, A., Bogowicz, M., Konukoglu, E., Riesterer, O., Balermpas, P., Guckenberger, M., . . . van Timmeren, J. E. (2022). A 2.5D convolutional neural network for HPV prediction in advanced oropharyngeal cancer. Comput Biol Med, 142, 105215. doi:https://doi.org/10.1016/j.compbiomed.2022.105215
  8. Li, J., Qiu, Z., Zhang, C., Chen, S., Wang, M., Meng, Q., . . . Zhang, X. (2022). ITHscore: comprehensive quantification of intra-tumor heterogeneity in NSCLC by multi-scale radiomic features. Eur Radiol. doi:https://doi.org/10.1007/s00330-022-09055-0
  9. Lombardo, E., Kurz, C., Marschner, S., Avanzo, M., Gagliardi, V., Fanetti, G., . . . Landry, G. (2021). Distant metastasis time to event analysis with CNNs in independent head and neck cancer cohorts. Sci Rep, 11(1), 6418. doi:https://doi.org/10.1038/s41598-021-85671-y
  10. Lv, W., Zhou, Z., Peng, J., Peng, L., Lin, G., Wu, H., . . . Lu, L. (2023). Functional-structural Sub-region Graph Convolutional Network (FSGCN): Application to the Prognosis of Head and Neck Cancer with PET/CT imaging. Computer Methods and Programs in Biomedicine. doi:https://doi.org/10.1016/j.cmpb.2023.107341
  11. Moitra, D., & Mandal, R. K. (2022). Classification of malignant tumors by a non-sequential recurrent ensemble of deep neural network model. Multimed Tools Appl, 1-19. doi:https://doi.org/10.1007/s11042-022-12229-z
  12. Zhinan, L., Wei, Z., Yudi, Y., Yabing, D., Yuanzhe, X., & Xiulan, L. (2022). Prediction of Human Papillomavirus (HPV) Status in Oropharyngeal Squamous Cell Carcinoma Based on Radiomics and Machine Learning Algorithms: A Multi-Cohort Study. Systematic Reviews in Pharmacy.

Publication Citation

Aerts HJWL, Velazquez ER, Leijenaar RTH, Parmar C, Grossmann P, Carvalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F, Rietbergen MM, Leemans CR, Dekker A, Quackenbush J, Gillies RJ, Lambin P. Decoding Tumour Phenotype by Noninvasive Imaging Using a Quantitative Radiomics Approach, Nature Communications, Volume 5, Article Number 4006, June 03, 2014. DOI: http://doi.org/10.1038/ncomms5006

TCIA Citation

Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7

Previous Versions

Version 2: Updated 2019/09/20

Added DICOM Segmentations

Title Data Type Format Access Points Studies Series Images License
Images DICOM
Clinical Data CSV

Version 1: Updated 2019/07/25

Title Data Type Format Access Points Studies Series Images License
Images DICOM
Clinical Data CSV
Analysis Results Using This Collection