The Cancer Imaging Archive uses multiple applications to facilitate our data hosting and downloads.  National Biomedical Imaging Archive (NBIA) software is used for radiology data that are submitted to us in DICOM format.  Aspera is used to provide downloads for other types of data such as digitized histopathology slides (e.g. *.SVS, *.TIFF) or radiology data in non-DICOM formats (e.g. NiFTI).