Head-Neck Cetuximab | Head-Neck Cetuximab
DOI: 10.7937/K9/TCIA.2015.7AKGJUPZ | Data Citation Required | 1.5k Views | 34 Citations | Image Collection
| Location | Species | Subjects | Data Types | Cancer Types | Size | Status | Updated | |
|---|---|---|---|---|---|---|---|---|
| Head-Neck | Human | 111 | PT, CT, RTDOSE, RTPLAN, RTSTRUCT, Protocol | Head and Neck Carcinomas | Image Analyses | Limited, Complete | 2013/11/14 |
Summary
This collection combines advanced molecular imaging treatment response assessment through pre- and post-treatment FDG PET/CT scans with therapy of advanced head and neck cancer, including chemo-radiation therapy with and without addition of an EGFR inhibitor molecular targeted agent (Cetuximab). The Head-Neck Cetuximab collection consists of a subset of image data from RTOG 0522, which was randomized phase III Trial of Radiation Therapy and Chemotherapy for stage III and IV Head and Neck carcinomas. The RTOG 0522 protocols were activated in November 2005 and successfully completed accrual of 945 patients in 2009. As part of the RTOG 0522 trial, CT, Structures, RT Doses, RT Plans were collected by RTOG, and institutions had the option to join a related quantitative PET (PET/CT) imaging study with ACRIN. The post-treatment FDG PET/CT scan was performed 8-9 weeks after completion of treatment before any nodal dissection. For more information about the original aims of this trial please see https://clinicaltrials.gov/ct2/show/results/NCT00265941?term=rtog0522 and this PDF.
Data Access
Some data in this collection contains images that could potentially be used to reconstruct a human face. Due to NIH Controlled Data Access Policy changes, downloads that previously required login-access are no longer available via TCIA. Watch for announcements re-enabling these in a new form.
Version 1: Updated 2013/11/14
| Title | Data Type | Format | Access Points | Subjects | License | Metadata | |||
|---|---|---|---|---|---|---|---|---|---|
| Images and Radiation Therapy Structures | PT, CT, RTDOSE, RTPLAN, RTSTRUCT | DICOM | 111 | 368 | 1,682 | 202,574 | NIH Controlled Data Access Policy | View | |
| Head-Neck Cetuximab (RTOG 0522) Trial Protocol | Protocol | CC BY 3.0 | — |
Additional Resources for this Dataset
The following external resources are not hosted or supported by TCIA, but may be useful to researchers utilizing this collection.
- ClinicalTrials.gov entry about the Trial NCT00265941, “Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With Stage III or Stage IV Head and Neck Cancer”
Citations & Data Usage Policy
Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:
Data Citation |
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Bosch, W. R., Straube, W. L., Matthews, J. W., & Purdy, J. A. (2015). Head-Neck Cetuximab [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2015.7AKGJUPZ |
Detailed Description
Supporting Documentation and metadata
Please note that 10 cases in this collection do not contain RT data.
Eight cases whose RT QA scores that were not “Per Protocol” or “Variation Acceptable” were excluded: 96, 133, 141, 143, 154, 182, 475, 478.
Also, subject 243 was ineligible and subject 260 expired prior to follow-up.
Related Publications
Publications by the Dataset Authors
The authors recommended the following as the best source of additional information about this dataset:
Publication Citation |
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Ang, K. K., Zhang, Q., Rosenthal, D. I., Nguyen-Tan, P. F., Sherman, E. J., Weber, R. S., Galvin, J. M., Bonner, J. A., Harris, J., El-Naggar, A. K., Gillison, M. L., Jordan, R. C., Konski, A. A., Thorstad, W. L., Trotti, A., Beitler, J. J., Garden, A. S., Spanos, W. J., Yom, S. S., & Axelrod, R. S. (2014). Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522. In Journal of Clinical Oncology (Vol. 32, Issue 27, pp. 2940–2950). American Society of Clinical Oncology (ASCO). https://doi.org/10.1200/jco.2013.53.5633 |
No other publications were recommended by dataset authors.
Research Community Publications
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