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HEAD-NECK-CETUXIMAB

The Cancer Imaging Archive

Head-Neck Cetuximab | Head-Neck Cetuximab

DOI: 10.7937/K9/TCIA.2015.7AKGJUPZ | Data Citation Required | 1.5k Views | 34 Citations | Image Collection

Location Species Subjects Data Types Cancer Types Size Supporting Data Status Updated
Head-Neck Human 111 PT, CT, RTDOSE, RTPLAN, RTSTRUCT, Protocol Head and Neck Carcinomas 52.36GB Image Analyses Limited, Complete 2013/11/14

Summary

This collection combines advanced molecular imaging treatment response assessment through pre- and post-treatment FDG PET/CT scans with therapy of advanced head and neck cancer, including chemo-radiation therapy with and without addition of an EGFR inhibitor molecular targeted agent (Cetuximab). 

The Head-Neck Cetuximab collection consists of a subset of image data from RTOG 0522, which was randomized phase III Trial of Radiation Therapy and Chemotherapy for stage III and IV Head and Neck carcinomas. The RTOG 0522 protocols were activated in November 2005 and successfully completed accrual of 945 patients in 2009. As part of the RTOG 0522 trial, CT, Structures, RT Doses, RT Plans were collected by RTOG, and institutions had the option to join a related quantitative PET (PET/CT) imaging study with ACRIN. The post-treatment FDG PET/CT scan was performed 8-9 weeks after completion of treatment before any nodal dissection. 

For more information about the original aims of this trial please see https://clinicaltrials.gov/ct2/show/results/NCT00265941?term=rtog0522 and this PDF.

Data Access

Some data in this collection contains images that could potentially be used to reconstruct a human face. Due to NIH Controlled Data Access Policy changes, downloads that previously required login-access are no longer available via TCIA. Watch for announcements re-enabling these in a new form.

Version 1: Updated 2013/11/14

Title Data Type Format Access Points Subjects Studies Series Images License Metadata
Images and Radiation Therapy Structures PT, CT, RTDOSE, RTPLAN, RTSTRUCT DICOM 111 368 1,682 202,574 NIH Controlled Data Access Policy View
Head-Neck Cetuximab (RTOG 0522) Trial Protocol Protocol PDF CC BY 3.0
Analysis Results Using This Collection
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Additional Resources for this Dataset

The following external resources are not hosted or supported by TCIA, but may be useful to researchers utilizing this collection.

Citations & Data Usage Policy

Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:

Data Citation

Bosch, W. R., Straube, W. L., Matthews, J. W., & Purdy, J. A. (2015). Head-Neck Cetuximab [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2015.7AKGJUPZ

Detailed Description

Supporting Documentation and metadata

Please note that 10 cases in this collection do not contain RT data.

Eight cases whose RT QA scores that were not “Per Protocol” or “Variation Acceptable” were excluded:  96, 133, 141, 143, 154, 182, 475, 478.

Also, subject 243 was ineligible and subject 260 expired prior to follow-up.

Related Publications

The authors recommended the following as the best source of additional information about this dataset:

Publication Citation

Ang, K. K., Zhang, Q., Rosenthal, D. I., Nguyen-Tan, P. F., Sherman, E. J., Weber, R. S., Galvin, J. M., Bonner, J. A., Harris, J., El-Naggar, A. K., Gillison, M. L., Jordan, R. C., Konski, A. A., Thorstad, W. L., Trotti, A., Beitler, J. J., Garden, A. S., Spanos, W. J., Yom, S. S., & Axelrod, R. S. (2014). Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522. In Journal of Clinical Oncology (Vol. 32, Issue 27, pp. 2940–2950). American Society of Clinical Oncology (ASCO). https://doi.org/10.1200/jco.2013.53.5633

No other publications were recommended by dataset authors.

Publication Citation

Ang, K. K., Zhang, Q., Rosenthal, D. I., Nguyen-Tan, P. F., Sherman, E. J., Weber, R. S., Galvin, J. M., Bonner, J. A., Harris, J., El-Naggar, A. K., Gillison, M. L., Jordan, R. C., Konski, A. A., Thorstad, W. L., Trotti, A., Beitler, J. J., Garden, A. S., Spanos, W. J., Yom, S. S., & Axelrod, R. S. (2014). Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522. In Journal of Clinical Oncology (Vol. 32, Issue 27, pp. 2940–2950). American Society of Clinical Oncology (ASCO). https://doi.org/10.1200/jco.2013.53.5633

Research Community Publications

TCIA maintains a list of publications which leverage our data. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.

TCIA maintains a list of publications that leveraged this dataset. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.

Other Publications Using this Data

TCIA maintains a list of publications which leverage our data. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.