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ARAR0331

The Cancer Imaging Archive

ARAR0331 | Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer

DOI: 10.7937/WTEC-MN22 | Data Citation Required | Image Collection

Location Species Subjects Data Types Cancer Types Size Supporting Data Status Updated
Head Human 108 MR, RTIMAGE, NM, CT, PT Nasopharyngeal 127.48GB Clinical Limited, Complete 2022/10/21

Summary

This collection contains data from the Children’s Oncology Group (COG) Clinical Trial NCT00274937, “Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer". Principal Investigator: Carlos Rodriguez-Galindo, MD.  It was sponsored by NCI and performed by the Children's Oncology Group under study number ARAR0331. This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells. Select patient-level data from this trial is available via the following link: https://nctn-data-archive.nci.nih.gov/node/1302.  

Trial Outcomes

Results of the trial have been reported in the following publications:

  • Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH. Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16. J Clin Oncol. 2019 Dec 10;37(35):3377-3391. doi: 10.1200/JCO.19.01692. Epub 2019 Oct 28.
  • Rodriguez-Galindo C, Krailo MD, Krasin MJ, Huang L, McCarville MB, Hicks J, Pashankar F, Pappo AS. Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study. J Clin Oncol. 2019 Dec 10;37(35):3369-3376. doi: 10.1200/JCO.19.01276. Epub 2019 Sep 25. Erratum in: J Clin Oncol. 2021 May 10;39(14):1602.

Data Access

This is a limited access data set. To request access please register an account on the NCTN Data Archive.  After logging in, use the “Request Data” link in the left side menu.  Follow the on screen instructions, and enter  NCT00274937 when asked which trial you want to request.  In step 2 of the Create Request form, be sure to select “Imaging Data Requested”. Please contact NCINCTNDataArchive@mail.nih.gov for any questions about access requests.

Version 1: Updated

Title Data Type Format Access Points Subjects Studies Series Images License
Images MR, RTIMAGE, NM, CT, PT DICOM
Download requires NBIA Data Retriever
108 803 7,010 330,052
Analysis Results Using This Collection
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ARAR0331-Tumor-Annotations
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Additional Resources for this Dataset

The National Cancer Institute (NCI) has created a centralized, controlled-access database, called the NCTN/NCORP Data Archive, for storing and sharing datasets generated from clinical trials of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP). Clinical data from the participants in this trial can be found at:

  • NCTN/NCORP Data Archive (Clinical Data)
  • Citations & Data Usage Policy

    Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:

    Data Citation

    Rodriguez-Galindo, C., Krailo, M. D., Krasin, M. J., Huang, L., McCarville, M. B., Hicks, J., Pashankar, F., & Pappo, A. S. (2022). Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer (ARAR0331) (Version 1) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/WTEC-MN22

    Detailed Description

    De-identification of DICOM dates

    De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard “Retain Longitudinal With Modified Dates Option” which allows dates to be retained as long as they are modified from the original date.  TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them.  Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.  This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients’ related imaging studies. 

    For example, if the real date of a patient’s registration was 03/27/2018 and the original imaging Study Date was 03/29/2018 then the “Days from registration” would be +2 and the anonymized TCIA Study Date would become 01/03/1960.

    Insertion of computed “REGISTRATION”/Days offset from registration” value

    In addition to modifying the actual date fields in the DICOM header, the “days from registration” values are calculated and stored in the DICOM tag (0012,0052) Longitudinal Temporal Offset from Event with the associated tag (0012,0053) Longitudinal Temporal Event Type set to “REGISTRATION”. 

    Note: If these DICOM tags are not present, DICOM tag (0012,0050) Clinical Trial Time Point ID with the associated tag (0012,0051) Clinical Trial Time Point Description provides this same information.  This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.

    Related Publications

    Publications by the Dataset Authors

    No related publications were found.

    Research Community Publications

    TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you’d like to add please contact the TCIA Helpdesk.

    Other Publications Using this Data

    TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you’d like to add please contact the TCIA Helpdesk.