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TCGA-KIRC-RADIOGENOMICS

TCGA-KIRC-Radiogenomics | Radiogenomics of Clear Cell Renal Cell Carcinoma: Preliminary Findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Research Group

DOI: 10.7937/K9/TCIA.2014.K6M61GDW | Data Citation Required | Analysis Result

Cancer Types Location Subjects Related Collections Size Supporting Data Updated
Renal Clear Cell Carcinoma Kidney 103 17KB Radiologist assessments of image features 2015/05/28

Summary

PURPOSE:

To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC).

MATERIALS AND METHODS:

This multi-institutional, multi-reader study included 103 patients (77 men; median age 59 years, range 34-79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%-33%, 34%-66% or >66%), growth pattern (endophytic, <50% exophytic, or ≥50% exophytic), and calcification (present, absent, or indeterminate)] were reviewed independently by three readers blinded to mutational data. The association of imaging features with mutational status (VHL, BAP1, PBRM1, SETD2, KDM5C, and MUC4) was assessed.

RESULTS:

Median tumor size was 49 mm (range 14-162 mm), 73 (71%) tumors had well-defined margins, 98 (95%) tumors were solid, 95 (92%) showed presence of necrosis, 46 (45%) had ≥50% exophytic component, and 18 (19.8%) had calcification. VHL (n = 52) and PBRM1 (n = 24) were the most common mutations. BAP1 mutation was associated with ill-defined margin and presence of calcification (p = 0.02 and 0.002, respectively, Pearson’s x2 test); MUC4 mutation was associated with an exophytic growth pattern (p = 0.002, Mann-Whitney U test).

CONCLUSIONS:

BAP1 mutation was associated with ill-defined tumor margins and presence of calcification; MUC4 mutation was associated with exophytic growth. Given the known prognostic implications of BAP1 and MUC4 mutations, these results support using radiogenomics to aid in prognostication and management.

Data Access

Version 1: Updated 2015/05/28

Title Data Type Format Access Points Subjects Studies Series Images License
Radiologist annotations, mutation status, and clinical variables CSV CC BY 3.0

Collections Used In This Analysis Result

Title Data Type Format Access Points Subjects Studies Series Images License
Corresponding Original MR Images from TCGA-KIRC CT, MR DICOM 103 118 738 49,815 CC BY 3.0

Citations & Data Usage Policy

Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:

Data Citation

Shinagare AB, Vikram R, Jaffe C, Akin O, Kirby J, Huang E, Freymann J, Sainani NI, Sadow CA, Bathala TK, Rubin DL, Oto A, Heller MT, Surabhi VR, Katabathina V, Silverman SG. (2014). Radiogenomics of Clear Cell Renal Cell Carcinoma: Preliminary Findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Research Group. The Cancer Imaging Archive. http://doi.org/10.7937/K9/TCIA.2014.K6M61GDW

Publications Using This Data

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Publication Citation

Shinagare, A. B., Vikram, R., Jaffe, C., Akin, O., Kirby, J., Huang, E., Freymann, J., Sainani, N. I., Sadow, C. A., Bathala, T. K., Rubin, D. L., Oto, A., Heller, M. T., Surabhi, V. R., Katabathina, V., & Silverman, S. G. (2015). Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas–Renal Cell Carcinoma (TCGA–RCC) Imaging Research Group. Abdominal Imaging, 40(6), 1684–1692. https://doi.org/10.1007/s00261-015-0386-z

TCIA Citation

Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7

Collections Used In This Analysis Result

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