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LUMINALB-BREAST-MR-ENHANCEMENT

The Cancer Imaging Archive

LuminalB-Breast-MR-Enhancement | Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging

DOI: 10.7937/K9/TCIA.2014.IIRMBUNX | Data Citation Required | Analysis Result

Cancer Types Location Subjects Related Collections Updated
Breast Cancer Breast 48 2014/11/12

Summary

Purpose

To investigate associations between breast cancer molecular subtype and semiautomatically extracted magnetic resonance (MR) imaging features.

Materials and Methods

Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive for 48 patients with breast cancer from four institutions in the United States were used in this institutional review board approval-exempt study. Computer vision algorithms were applied to extract 23 imaging features from lesions indicated by a breast radiologist on MR images. Morphologic, textural, and dynamic features were extracted. Molecular subtype was determined on the basis of genomic analysis. Associations between the imaging features and molecular subtype were evaluated by using logistic regression and likelihood ratio tests. The analysis controlled for the age of the patients, their menopausal status, and the orientation of the MR images (sagittal vs axial).

Results

There is an association (P = .0015) between the luminal B subtype and a dynamic contrast material-enhancement feature that quantifies the relationship between lesion enhancement and background parenchymal enhancement. Cancers with a higher ratio of lesion enhancement rate to background parenchymal enhancement rate are more likely to be luminal B subtype.

Conclusion

The luminal B subtype of breast cancer is associated with MR imaging features that relate the enhancement dynamics of the tumor and the background parenchyma.

(c) RSNA, 2014

Online supplemental material is available for this article.

Collections Used In This Analysis Result

Title Data Type Format Access Points Subjects Studies Series Images License
Original Image Data from TCGA-BRCA MR DICOM 48 51 528 55,953 CC BY 3.0

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Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:

Data Citation

Mazurowski MA, Zhang J, Grimm LJ, Yoon SC, and Silber JI. (2014). Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging (LuminalB-Breast-MR-Enhancement). The Cancer Imaging Archive. DOI: 10.7937/K9/TCIA.2014.IIRMBUNX

Related Publications

Publications by the Dataset Authors

No publications by dataset authors were found.

Publication Citation

Mazurowski, M. A., Zhang, J., Grimm, L. J., Yoon, S. C., & Silber, J. I. (2014). Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging. Radiology. Radiological Society of North America (RSNA). DOI: 10.1148/radiol.14132641

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Publication Citation

Mazurowski, M. A., Zhang, J., Grimm, L. J., Yoon, S. C., & Silber, J. I. (2014). Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging. Radiology. Radiological Society of North America (RSNA). DOI: 10.1148/radiol.14132641